These are the foods that are most linked to pancreatic cancer

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Despite the vast experience and evidence that currently exists around the different types of cancer, the Pancreatic cancer remains one of the deadliest, specifically pancreatic ductal adenocarcinoma: it is not one of the most frequent, but it is the 4th most lethal, with a five-year survival of around 10% of diagnosed patients. Therefore, its prevention and treatment are essential.

The most cases of pancreatic cancer arise from precancerous lesions known as pancreatic intraepithelial neoplasia. It is estimated that between 55-80% of adults over the age of 40 have these silent low-grade lesions, and it is now known that certain lifestyle factors can activate them.

This would be suggested by a new study published in Nature Communications: Precancerous pancreatic lesions in mice, similar to those in humans, contain elevated levels of a receptor sensitive to factors such as a high-fat dietamong other risk factors.

This is how the silent pancreatic cancer is “activated”

The study, led by Imad Shireiqi, would suggest that these precancerous pancreatic lesions from mice and humans contain high levels of the transcriptional peroxisome proliferator-activated receptor delta or PPARδ. This receptor regulates the expression of various key genes in fat metabolism, and also in the formation or ‘activation’ of pancreatic cancer.

if activated PPARδ dramatically accelerates the progression of these silent lesions into active cancer, not only in the pancreas but also in other types of gastrointestinal cancer. However, as Shireiqi explains, there is very limited information on the role of this receptor in pancreatic cancer in particular.

Activation of this receptor has been linked to excessive exposure to certain factors, both natural and synthetic. One such factor would be high fat dieta type of diet usually associated with a increased risk of pancreatic cancer in both humans and animals: fatty acids are natural activators of PPARδ.

Other factors that would activate this receptor would be substances such as Cardarine (GW501516), a drug found in some types of exercise supplements, intended to increase both physical performance and endurance. Cardarine was originally designed to encourage the body to burn more fat and treat conditions such as hyperlipidemia or obesity. However the development of this drug and other PPARδ receptor activators has stalled for a long time given its relationship with possible procancerous side effects.

However, and despite the fact that this relationship has been known since 1999, although the drug is not sold for that purpose, many points of sale on the internet without regulation do continue to sell Cardarine in the form of sports supplementation. Initially studies in mice seemed to help reduce their fatigue, but its side effects were not discussed in the media as a pro-cancer substance: Cardarine and other PPARδ activators ‘help’ cancer cells get more energy through fats, using them as a fuel source.

Currently, the risk factors that would activate precancerous pancreatic lesions remain poorly defined, and the researchers point out that the majority of these lesions never become cancer, but understanding how the transition from benign to malignant occurs is crucial to develop Effective interventions against pancreatic cancer.

In this case, the study would suggest that both a high-fat diet and synthetic PPARδ activating factors, such as Cardarine, would be elements to avoid. Likewise, in the future, the researchers intend to develop some type of blockade of the activation of this receptor, in addition to encouraging the population to reduce their intake of high-fat diets, especially in the case of having large precancerous lesions. .

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